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In addition to its own tenders, the Faculty of Medicine also welcomes the external acquisition of appropriate research projects and supports the candidates to realize them. Bagutski, D.

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This reduction in fluorescence turned out to be dose-dependent with respect to the inhibitor concentration, and an IC50 of 8. While all of the studied compounds lead to an accumulation of the fluorescent dyes, varying effects on the ATPase activity can be observed, allowing classification of the compounds either as ATPase inhibitors or activators. EMBO J.

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Brown, Chem. Two types of selective, non-competitive, inhibitors have been characterized, either inhibiting or stimulating the basal ATPase activity. RNAi experiments revealed a role for RON in cell migration, colony-forming potential in vitro and survival and extravasation in a zebrafish model in vivo.

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Xie, V. Many analogues of staurosporine 1a potent but non-specific lead, have been synthesised in order to advance kinase inhibition potential Peifer, C.

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Synthesis— The kDa Heat shock protein Hsp90 is an ATP-dependent chaperone known to play a crucial role in protein homeostasis.

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There are seven human isotypes which differ in their subcellular localization, their enzymatic activities as well as in their deacylation substrates. Geological Survey of Denmark and Greenland.

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